A patient is suspected of having HS. However, there appear to be

Question

A patient is suspected of having HS. However, there appear to be <1% spherocytes on the peripheral blood smear, and the osmotic fragility test is normal. What test could be performed to increase the sensitivity of testing for HS?
A) Incubated osmotic fragility test
B) Immunophenotyping for CD55 and CD59
C) Sucrose hemolysis test
D) Ham test

Quizplus · Accepted Answer

The incubated osmotic fragility test increases the sensitivity of testing for Hereditary Spherocytosis (HS) by incubating the red blood cells at 37°C for 24 hours before performing the osmotic fragility test, which can reveal an increased fragility not apparent in the standard test.

A Patient Is Suspected of Having HS