All of the following statements characterize Down syndrome EXCEPT:

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Down syndrome is caused by trisomy of chromosome 21, which means there are three copies of this chromosome instead of the usual two. Cardiac abnormalities, intussusceptions, and gastric reflux are common signs of Down syndrome. Individuals with Down syndrome may have upward slanting of the eyes and short hands and fingers. Chromosomal inversion is not a known cause of Down syndrome.

All of the Following Statements Characterize Down Syndrome EXCEPT