Papillon-Lefèvre syndrome is caused by a mutation in the:

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Papillon-Lefèvre syndrome (PLS) is caused by a mutation in the Cathepsin C gene, which encodes an enzyme essential for the activation of many proteases, including several involved in the immune response. This mutation leads to a deficiency in the enzyme, which impairs the body's ability to remove dead skin cells, resulting in hyperkeratosis (thickening of the skin) and periodontitis (inflammation of the gums).

Papillon-Lefèvre Syndrome Is Caused by a Mutation in The