A Client's Hormone Replacement Therapy for a Health Problem Has

A client's hormone replacement therapy for a health problem has been discontinued.The nurse should instruct the client about which effects because the therapy has been stopped?
Select all that apply.

A) Body cells will need time to adjust to the new hormone level.
B) Target cells are desensitized and are less responsive to the effects of the hormone.
C) Body cells will create more receptors on the plasma membrane to capture hormone molecules.
D) Body cells will send signals that hormone action is needed.
E) Body cells will secrete more hormone.