What is the mechanism by which binding of testosterone to the testosterone receptor leads to upregulated gene transcription?
A)Binding of testosterone to the testosterone receptor leads to the increase in second messengers that activate a kinase cascade,ultimately leading to the activation of transcription factors that promote gene transcription.
B)Binding of testosterone to the testosterone receptor leads to the activation of a G protein that stimulates the activation of enzymes that promote gene transcription.
C)Binding of testosterone to the testosterone receptor leads to a conformational change that allows the receptor to enter the nucleus where it can bind to DNA and promote gene transcription.
D)Binding of testosterone to the testosterone receptor leads to the opening of an ion channel that leads to an increase in calcium in the cytoplasm.The increased calcium levels activate calmodulin,which can go on to activate other proteins that promote gene transcription.

Question

Quizplus · Accepted Answer

When testosterone binds to the testosterone receptor, the receptor undergoes a conformational change that allows it to enter the nucleus. Once in the nucleus, the receptor can bind to specific DNA sequences known as hormone response elements (HREs) and recruit co-activator proteins that promote gene transcription. This results in increased mRNA production and ultimately, increased protein synthesis.

What Is the Mechanism by Which Binding of Testosterone to the Testosterone