If we want to make comparisons between two groups that we know are different at the start of the experiment, the design to use is:

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The nonequivalent before-after design is used to compare groups that are known to be different at the outset. This design acknowledges the pre-existing differences between groups and attempts to measure the effect of an intervention by comparing outcomes before and after the intervention within each group.

If We Want to Make Comparisons Between Two Groups That