The single most important factor that will limit the usefulness of calorie restriction in humans is:

Question

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Adhering to a 25% or more reduction in calories can be challenging for most people, and sustainability in the long-term is even harder. Therefore, this factor will significantly limit the usefulness of calorie restriction in humans. Nutrient deficiencies and underweight-related physiological diseases/disorders can be managed through careful monitoring and proper nutrient supplementation, and our already long life span is not a limiting factor by itself.

The Single Most Important Factor That Will Limit the Usefulness