What area of the brain is generally considered to be the location for the start,or pre-clinical pathology,of Alzheimer's disease?

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The entorhinal cortex is considered to be the location for the start or pre-clinical pathology of Alzheimer's disease. This area of the brain is involved in memory and spatial navigation and is one of the first areas to show pathology in Alzheimer's disease. The hippocampus, which is also involved in memory, is affected later in the disease progression.

What Area of the Brain Is Generally Considered to Be