List three examples of a single gene disorder where there is extremely limited mutational heterogeneity and one example where different mutations in one gene result in a wide range of different diseases.

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The Answer is Sickle cell anemia results from a very limited range of mutations that each produce a change at amino acid position 6 in the beta globin chain, converting the normal glutamate to valine. Huntington disease is always caused by a modest expansion in the number of tandem CAG repeats within an array of these repeats located within exon 1. Achondroplasia is caused exclusively by mutation at a single nucleotide, producing a glycine to arginine substitution at amino acid position 380 in the FGFR3 (fibroblast growth factor receptor type 3) protein.
Different mutations in the LMNA (lamin A) gene can result in a wide variety of disorders, including different types of lipodystrophy, muscular dystrophy, cardiomyopathy, and progeria plus a neuropathy, Charcot-Marie-Tooth disease type 2B1.

List Three Examples of a Single Gene Disorder Where There