When There Is a Known Job Opening

When there is a known job opening,

A) you should take the time to learn something about the company to make a case of your own related expertise.
B) you should go in person with your résumé and wait for someone to agree to see you.
C) you should send in your résumé and a cover letter and call daily until they interview you.
D) you should send in your résumé with a handwritten note and follow up in a few days.