Which intervention would be considered to reduce accumulation of a drug in a patient who has decreased liver function?
A) Decreasing the time interval between dosages
B) Reducing the dosage
C) Administering the medication intravenously
D) Changing the drug to one that has a longer half-life

Question

Quizplus · Accepted Answer

Decreasing the dosage would be the best choice. When there is decreased liver function, the drug metabolism may be impaired, leading to a higher plasma concentration of the drug. Reducing the dosage would therefore help to decrease the amount of the drug in the patient's system and prevent toxicity.

Which Intervention Would Be Considered to Reduce Accumulation of a Drug