Which of the following statements about the classical pathway of complement activation is FALSE?
A) Cleaved fragments of some of the proteins act to increase inflammation.
B) The C1 protein complex is initiated by antigen-antibody complexes.
C) C3b causes opsonization.
D) C3 is not involved in the classical pathway.
E) C1 is the first protein activated in the classical pathway.

Question

Quizplus · Accepted Answer

C3 is actually an important part of the classical pathway, as it is cleaved into C3a and C3b by the C1 complex and C4b2a complex. C3b then contributes to opsonization and the formation of the membrane attack complex.

Which of the Following Statements About the Classical Pathway of Complement