Several inherited deficiencies in the complement system occur in humans.Which of the following would be the MOST severe?
A)deficiency of C3
B)deficiency of C5
C)deficiency of C6
D)deficiency of C7
E)deficiency of C8

Question

Quizplus · Accepted Answer

C3 is the central component of the complement system and its deficiency leads to the inability to generate C3b, impairing both the classical and alternative pathways. This deficiency is associated with recurrent infections and an increased vulnerability to autoimmune diseases, making it the most severe of the options listed. Deficiencies in C5, C6, C7, and C8 are less severe and may present with a milder phenotype.

Several Inherited Deficiencies in the Complement System Occur in Humans