Which of the following statements about the classical pathway of complement activation is FALSE?
A)C1 is the first protein activated in the classical pathway.
B)The C1 protein complex is initiated by antigen-antibody complexes.
C)C3 is not involved in the classical pathway.
D)Cleaved fragments of some of the proteins act to increase inflammation.
E)C3b causes opsonization.

Question

Quizplus · Accepted Answer

C3 is actually involved in the classical pathway, as it gets cleaved to C3a and C3b by the C3 convertase enzyme. C3b can then bind to the surface of pathogens and triggers opsonization. Therefore, statement C is false.

Which of the Following Statements About the Classical Pathway of Complement