What might occur if a mutation in the leptin receptor causes it to be always activated, even in the absence of leptin?
A) "JAK2 will be activated."
B) "$\alpha$-MSH secretion will be low."
C) "NPY secretion will be high."
D) "AGRP secretion will be high."

Question

Quizplus · Accepted Answer

Leptin receptors, when activated, signal through pathways including the JAK2 (Janus kinase 2) pathway. If the receptor is always activated, it would continuously activate JAK2, regardless of leptin presence.

What Might Occur If a Mutation in the Leptin Receptor α\alphaα

What Might Occur If a Mutation in the Leptin Receptor $\alpha$