The chemotherapy agent 5-fluorouracil is usually degraded by which of the following enzymes, which requires administration of higher doses?
A) "$\beta$-ureidopropionase"
B) "thymidine phosphorylase"
C) "dihydropyrimidine dehydrogenase"
D) "dihydropyrimidinase"

Question

Quizplus · Accepted Answer

5-fluorouracil is degraded by dihydropyrimidine dehydrogenase, which requires higher doses of the drug for sufficient metabolism. Option A is a fabricated enzyme name and option B is actually involved in activating 5-fluorouracil. Option D is not involved in the degradation of 5-fluorouracil.

The Chemotherapy Agent 5-Fluorouracil Is Usually Degraded by Which of the Following