The poison compound 1080 converts fluoroacetate to fluorocitrate. Which enzyme in the citrate cycle is inhibited by this poison?
A) "aconitase"
B) "citrate synthase"
C) "isocitrate dehydrogenase"
D) "$\alpha$-ketoglutarate dehydrogenase"

Question

Quizplus · Accepted Answer

Aconitase is inhibited by fluorocitrate, which is produced when fluoroacetate is converted to fluorocitrate by the action of the poison compound 1080. This inhibition disrupts the citric acid cycle, leading to toxic effects.

The Poison Compound 1080 Converts Fluoroacetate to Fluorocitrate α\alphaα -Ketoglutarate Dehydrogenase

The Poison Compound 1080 Converts Fluoroacetate to Fluorocitrate $\alpha$ -Ketoglutarate Dehydrogenase