An important issue for depressed patients prescribed codeine for pain is that:
A)several common SSRIs block the conversion of codeine to morphine.
B)decreased number of SSRIs cause codeine to be converted to heroin.
C)it causes significant respiratory depression in these individuals.
D)drug combinations reduce the effectiveness of codeine down to about 1 hour.

Question

Quizplus · Accepted Answer

Several common SSRIs (selective serotonin reuptake inhibitors) can block the conversion of codeine to its active form, morphine, which can lead to reduced pain relief and potential negative side effects. It is important for clinicians to consider this drug interaction when prescribing opioids for depressed patients on SSRIs.

An Important Issue for Depressed Patients Prescribed Codeine for Pain