Initiator proteins bind to replication origins and disrupt hydrogen bonds between the two DNA strands being copied.Which of the factors below does not contribute to the relative ease of strand separation by initiator proteins?

Question

Quizplus · Accepted Answer

The ease of strand separation by initiator proteins is primarily due to the fact that replication origins are rich in A-T base pairs, which only require two hydrogen bonds to be broken as opposed to the three needed for G-C base pairs. Initiator proteins also only separate a few base pairs at a time, which reduces the energy needed for strand separation. Additionally, once opened, other proteins of the DNA replication machinery bind to the origin to stabilize the unwound DNA strands. The reaction occurring at room temperature is not a factor in the ease of strand separation by initiator proteins.

Initiator Proteins Bind to Replication Origins and Disrupt Hydrogen Bonds