Homologous recombination is an important mechanism in which organisms use a "backup" copy of the DNA as a template to fix double-strand breaks without loss of genetic information.Which of the following is NOT necessary for homologous recombination to occur?

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Homologous recombination requires 3′ DNA strand overhangs, not 5′ overhangs, to initiate the process. These overhangs invade the homologous DNA sequence to begin repair. Sequence similarity is necessary for the strands to align correctly, and nucleases are needed to process the DNA ends to generate the 3′ overhangs.

Homologous Recombination Is an Important Mechanism in Which Organisms Use