A poison added to an in vitro translation mixture containing mRNA molecules with the sequence 5′-AUGAAAAAAAAAAAAUAA-3′ has the following effect: the only product made is a Met-Lys dipeptide that remains attached to the ribosome.What is the most likely way in which the poison acts to inhibit protein synthesis?

Question

Quizplus · Accepted Answer

The poison likely inhibits the movement of the small subunit relative to the large subunit, preventing the ribosome from translocating and thus stopping translation after the formation of the Met-Lys dipeptide.

A Poison Added to an in Vitro Translation Mixture Containing