Which of the Following Statements About Transcriptional Regulators Is FALSE

Which of the following statements about transcriptional regulators is FALSE?

A) Transcription regulators interact only with the sugar-phosphate backbone on the outside of the double helix to determine where to bind on the DNA helix.
B) Transcription regulators will form hydrogen bonds, ionic bonds, and hydrophobic interactions with DNA.
C) The DNA-binding motifs of transcription regulators usually bind in the major groove of the DNA helix.
D) The binding of transcription regulators generally does not disrupt the hydrogen bonds that hold the double helix together.