Meiosis includes a recombination checkpoint that is analogous to the checkpoints in cell-cycle progression.Double-strand breaks in the DNA initiate recombination in meiosis.The broken end of a DNA molecule finds the corresponding sequence on a homologous chromosome and exchanges a chromosomal segment with its homolog, thereby repairing the break.Ongoing recombination sends a negative regulatory signal that prevents cells from entering meiotic division I.
A.Mutations in several genes inactivate the recombination checkpoint.What do you predict will happen if a cell proceeds through meiotic division I before completing recombination?
B.What will happen if a cell fails to initiate recombination and proceeds through meiotic division I? Meiotic division II?

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The Answer of Meiosis includes a recombination checkpoint that is analogous to the checkpoints in cell-cycle progression.Double-strand breaks in the DNA initiate recombination in meiosis.The broken end of a DNA molecule finds the corresponding sequence on a homologous chromosome and exchanges a chromosomal segment with its homolog, thereby repairing the break.Ongoing recombination sends a negative regulatory signal that prevents cells from entering meiotic division I.
A.Mutations in several genes inactivate the recombination checkpoint.What do you predict will happen if a cell proceeds through meiotic division I before completing recombination?
B.What will happen if a cell fails to initiate recombination and proceeds through meiotic division I? Meiotic division II?

Meiosis Includes a Recombination Checkpoint That Is Analogous to the Checkpoints