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Gene a Is Located near Gene B on Chromosome 13

Question 49

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Gene A is located near gene B on Chromosome 13 in humans.A mutation in the germ line of an individual with the haplotype AB generates gametes with the genotype Ab.Many descendants of this founder individual carry the b mutation, which predisposes carriers to high blood pressure.Initially, all descendants who inherit the b mutation also inherit the neighboring A allele.Through the generations, fewer and fewer descendants with the b mutation carry the A allele, and instead they have the a allele.(Individuals with A and a are equally healthy and fit.) Explain how the b and A alleles are separated.

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Eventually, the b mutation will be separ...

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