A 65-year-old woman with a history of congestive heart failure, osteoarthritis, and hypertension presents with pain and tenderness, which is relieved by food or antacids. Upper endoscopy reveals a gastric ulcer. Her current medications include digoxin, metoprolol, lisinopril, aspirin, and hydrochlorothiazide. Which of her medications is most likely to have contributed to her peptic ulcer disease?
A) Digoxin
B) Metoprolol
C) Lisinopril
D) Aspirin
E) Hydrochlorothiazide

Question

Quizplus · Accepted Answer

Aspirin is known to contribute to peptic ulcer disease due to its ability to inhibit the production of protective gastric mucosal prostaglandins, leading to increased gastric acid secretion and reduced mucosal protection.

A 65-Year-Old Woman with a History of Congestive Heart Failure