A 17-year-old girl comes to see an endocrinologist because of primary amenorrhea. Breast development started several years ago, and she has otherwise been well. On examination breast development and height is in the tenth percentile, but she has no pubic or axillary hair. A pelvic examination reveals a blind vagina. These findings are most consistent with which of the following?
A) Turner's syndrome
B) Hypopituitarism
C) Androgen insensitivity
D) Klinefelter's syndrome
E) Adrenogenital syndrome

Question

Quizplus · Accepted Answer

Androgen insensitivity syndrome is characterized by a female phenotype in an individual with a 46,XY karyotype due to resistance to androgens. This results in normal breast development from estrogen but lack of pubic and axillary hair, primary amenorrhea, and a blind-ending vagina because the individual is genetically male and does not develop a uterus or ovaries.

A 17-Year-Old Girl Comes to See an Endocrinologist Because of Primary