Which of the Following Is NOT a Potential Advantage of Gene

Which of the following is NOT a potential advantage of gene therapy over traditional pharmacologic therapy?

A) Gene therapy can replace a mutant gene that results in disease, thereby striking the root of the condition.
B) Gene therapy can result in continuous production of a therapeutic protein with a short t_1/2 that would otherwise require frequent dosing.
C) Gene therapy in Phase 4 studies has been proven safer and more efficacious than analogous drug treatments.
D) Gene therapy can be targeted to a specific site or cell type to avoid potentially toxic systemic therapy.
E) Gene therapy can improve patient compliance dramatically, since it does not rely on daily adherence to a treatment.