Which of the following is the correct order of decreasing leaving group ability in nucleophilic acyl substitutions (better leaving group worse leaving group)? A) Cl− NH₂− CH₃O− B) NH₂− CH₃O− Cl− C) Cl− CH₃O− NH₂− D) CH₃O− Cl− NH₂−

Question

Which of the following is the correct order of decreasing leaving group ability in nucleophilic acyl substitutions (better leaving group > worse leaving group)? A) Cl− > NH₂− > CH₃O− B) NH₂− > CH₃O− > Cl− C) Cl−> CH₃O− > NH₂− D) CH₃O− > Cl− > NH₂−

Quizplus · Accepted Answer

Leaving group ability is generally determined by the stability of the leaving group as an anion. Chloride (Cl−) is a better leaving group than methoxide (CH₃O−) and amide (NH₂−) because it is a weaker base and more stable as an anion.

Which of the Following Is the Correct Order of Decreasing