Which of the following best describes the key mechanistic steps in the reaction of an anhydride and an amine to form an amide?
A) addition followed by elimination
B) elimination followed by addition
C) substitution followed by addition
D) addition followed by decarboxylation

Question

Quizplus · Accepted Answer

The reaction between an anhydride and an amine to form an amide involves an initial nucleophilic addition of the amine to the carbonyl carbon of the anhydride. This is followed by the elimination of a carboxylate group, completing the formation of the amide.

Which of the Following Best Describes the Key Mechanistic Steps