Which of the following is the correct order of decreasing reactivity in hydrolysis reactions (more reactive less reactive)?
A) esters amides acid chlorides
B) amides acid chlorides esters
C) acid chlorides esters amides
D) esters acid chlorides amides

Question

Which of the following is the correct order of decreasing reactivity in hydrolysis reactions (more reactive > less reactive)?
A) esters > amides > acid chlorides
B) amides > acid chlorides > esters
C) acid chlorides > esters > amides
D) esters > acid chlorides > amides

Quizplus · Accepted Answer

Acid chlorides are the most reactive towards hydrolysis due to the high electrophilicity of the carbonyl carbon, followed by esters which are less reactive, and amides are the least reactive because of the strong resonance stabilization between the lone pair on the nitrogen and the carbonyl group.

Which of the Following Is the Correct Order of Decreasing