The Nef protein from HIV causes a reduction in the amount of the MHC 1 protein on the surface of infected CD4 positive T cells.Which of the following is the result of this process?

Question

Quizplus · Accepted Answer

MHC 1 proteins are responsible for presenting viral antigens to cytotoxic T cells, which then recognize and destroy infected cells. When the level of MHC 1 proteins on the surface of infected CD4 T cells is reduced by Nef, the immune system cannot detect the presence of the virus and the infected cells are not eliminated. Therefore, choice D is the best option as it correctly describes the consequence of the reduction of MHC 1 proteins on the surface of HIV-infected T cells.

The Nef Protein from HIV Causes a Reduction in the Amount