Mutations in Bacterial Porins Typically Lead to Antibiotic Resistance by

Mutations in bacterial porins typically lead to antibiotic resistance by

A) changing the orientation of the porin α-helical transmembrane segments to constrict the size of the channel.
B) changing the stereoisomer specificity of the porin transport.
C) blocking diffusion of the antibiotic through the porin channel.
D) disrupting the voltage difference across the porin channel.
E) reversing water transport through the channel.