The Rate of a Reaction Catalyzed by an Enzymes Usually

The rate of a reaction catalyzed by an enzymes usually ________ with temperature; however,at temperatures above the optimum range ________.

A) increases; protein denaturation occurs
B) increases; the reaction proceeds without the enzyme
C) decreases; the reaction proceeds without the enzyme
D) increases; the direction of the reaction reverses
E) decreases; prosthetic groups are necessary