Question 1

Wiskott-Aldrich syndrome (WAS)is a sex-linked recessive blood disorder that results when an individual does not have a functional WAS gene.Explain where a functional WAS gene can be isolated and how genetic engineering could be used to treat a patient who has WAS.

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Question 2

Why are dominant genetic disorders more rare than recessive disorders?

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Question 3

Describe the possible genotypes and phenotypes (include probabilities)of offspring from a cross between a female heterozygous for the X-linked allele that produces Wiskott-Aldrich syndrome (WAS)and a male who does not have WAS.

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Question 4

If DNA testing reveals that Tina carries a single allele for a particular genetic disorder but she does not currently show symptoms of the disease,is it possible that she will develop the disease later in life? Explain.

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Question 5

Does the pedigree shown below most likely represent a condition that is autosomal recessive,dominant,or sex-linked? Explain your reasoning.

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Question 6

During routine genetic testing before the 2014 NBA Draft former Baylor Bears' basketball center Isaiah Austin was diagnosed with Marfan syndrome.This genetic condition results in connective tissue problems for the individual.One of the more life-threatening features of this condition is aortic enlargement,which can leave the aorta susceptible to rupture.In 75 percent of the cases,the allele is inherited from one parent; in the other 25 percent of the cases,a new mutation has occurred.Explain whether this condition is likely an autosomal disorder (recessive or dominant)or an X-linked disorder; support your answer with information from the infographic shown below.

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Question 7

What characteristics of inheritance would allow you to distinguish whether a disorder is recessive autosomal,dominant autosomal,or sex-linked?

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Quiz 8: Chromosomes and Human Genetics