What is true about new nucleosome formation during DNA replication?
A)Nucleosomes will be composed of different combinations of H3/H4 tetramers and H2A/H2B that are either newly synthesized or were from previous histone octamers.
B)Nucleosomes will be composed of different combinations of H3/H2A tetramers and H4/H2B that are either newly synthesized or were from previous histone octamers.
C)One DNA strand will have newly synthesized octamers and the other will have previously synthesized octamers.
D)Nucleosomes will be composed of different combinations of H2A/H2B/H3/H4 tetramers that are either newly synthesized or were from previous histone octamers.

Question

Quizplus · Accepted Answer

During DNA replication, nucleosomes are disassembled ahead of the replication fork and then reassembled on the newly synthesized DNA. The new nucleosomes are composed of a mix of old and new histones. Specifically, the H3/H4 tetramers are partially retained from the original nucleosome and can associate with newly synthesized H2A/H2B dimers to form new nucleosomes. This ensures the preservation of some of the original histone modifications and thus some of the epigenetic information.

What Is True About New Nucleosome Formation During DNA Replication