Suppose a cell lacks functional Shugoshin.What is the predicted effect on cohesin?
A)Cohesin will be cleaved prior to metaphase in mitosis.
B)Cohesin will not be cleaved during mitosis or meiosis.
C)Cohesin at the centromeres of sister chromatids will be cleaved during meiosis I.
D)Cohesin on the arms of sister chromatids will be cleaved during meiosis II.
E)Cohesin will be cleaved normally during mitosis and meiosis I.

Question

Quizplus · Accepted Answer

Shugoshin protects cohesin at the centromeres during meiosis I. Without functional Shugoshin, cohesin at the centromeres will be cleaved during meiosis I, leading to premature separation of sister chromatids.

Suppose a Cell Lacks Functional Shugoshin