How can databases of variants be used to help pinpoint a disease-causing mutation? (Select all that apply. )
A)Polymorphisms found in individuals that do not have the syndrome can be eliminated from consideration.
B)Common polymorphisms are unlikely to cause a rare disease and they can be eliminated from consideration.
C)Some amino acids are conserved in genes across species; mutations in conserved amino acids are not likely to cause disease.
D)Mutations that occur between genes are most likely to cause a genetic disease.

Question

Quizplus · Accepted Answer

Databases of variants can help eliminate polymorphisms found in healthy individuals (A) and common polymorphisms unlikely to cause rare diseases (B), narrowing down potential disease-causing mutations.

How Can Databases of Variants Be Used to Help Pinpoint