Identifying candidates for a disease gene by positional cloning depends on distinguishing DNA markers that are close to the disease gene from markers that are far away.When the disease gene is close to a marker, there will be
A)a high number of mutations in the intervening DNA.
B)a low rate of recombination between the disease gene and the marker.
C)many alleles at the marker locus.
D)a high chance of locus heterogeneity.

Question

Quizplus · Accepted Answer

A low rate of recombination between the disease gene and the marker indicates physical proximity, as genes that are close together on a chromosome are less likely to be separated during recombination events.

Identifying Candidates for a Disease Gene by Positional Cloning Depends