If a chemical inhibitor of DNA ligase was added to bacterial cells after DNA replication initiation, the outcome would be
A)elongation of both strands would not occur without ligase to join new nucleotides together.
B)elongation would occur, but Okazaki fragments would not be joined together.
C)elongation of the lagging strand, but not the leading strand would occur.
D)normal replication would proceed as DNA ligase is not required for this process.
E)too many supercoils would build up in the DNA, resulting in a halting of elongation.

Question

Quizplus · Accepted Answer

DNA ligase is crucial for joining Okazaki fragments on the lagging strand during DNA replication. Elongation can still occur, but without ligase, the fragments cannot be joined to form a continuous strand.

If a Chemical Inhibitor of DNA Ligase Was Added to Bacterial