Increased glutamate from stress may produce a state of sadness from dopamine depletion to trigger cravings for increased dopamine by using drugs, thereby increasing risk of

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Increased glutamate from stress can lead to dopamine depletion, which may cause cravings for substances that increase dopamine levels, thus increasing the risk of drug relapse as individuals seek to alleviate feelings of sadness or discomfort.

Increased Glutamate from Stress May Produce a State of Sadness