Misexpression of the Pax6 Gene Was Shown to Promote Eye

Misexpression of the Pax6 gene was shown to promote eye development in both vertebrates and invertebrates.The authors of this study suggested that this was evidence that eyes evolved only once.What other evidence contradicts this view?

A) Invertebrates normally have only simple eyespots.
B) Many different transcription factors can initiate eye development when misexpressed.
C) While the anatomy of all animal eyes is the same, lens proteins vary greatly.
D) The anatomical structure of insect, mollusk, and vertebrate eyes are quite different.