Tumor suppressor proteins can assist in slowing down the cell cycle under appropriate conditions. In humans, the TP53 gene encodes a tumor suppressor called p53. Most mutations in the TP53 gene result in a mutant form of p53 that can no longer function to slow down the cell cycle, which can lead to a cell becoming cancerous. However, some mutant forms of p53 actually possess the ability to increase a cell's resistance to anticancer treatments. Which of the following BEST describes this type of mutation?

Question

Quizplus · Accepted Answer

A gain-of-function mutation results in a protein acquiring new or enhanced activities. In this case, the mutant p53 not only loses its original function but also gains a new function that increases resistance to anticancer treatments.

Tumor Suppressor Proteins Can Assist in Slowing Down the Cell