A 45- year- old female was evaluated for fatigue, lethargy, and a 25- pound weight gain since her las physical. Her face was slightly puffy, and her neck was slightly swollen. Laboratory results were as What is the most likely diagnosis?
Complete blood count (CBC)—within normal limits
Urinalysis—within normal limits
Renal function tests (BUN and creatinine)—within normal limits
Electrolytes and glucose—within normal limits
Antinuclear antibody (ANA)—negative
Antithyroid peroxidase antibody (anti-TPO)—negative
Antithyroglobulin antibody (anti-TG)—positive
TSH-receptor antibody (TRAb)—negative
Total thyroxine hormone (T4)—low
Thyroid stimulating hormone (TSH)—high

Question

A 45- year- old female was evaluated for fatigue, lethargy, and a 25- pound weight gain since her las physical. Her face was slightly puffy, and her neck was slightly swollen. Laboratory results were as What is the most likely diagnosis? 
Complete blood count (CBC)—within normal limits
Urinalysis—within normal limits
Renal function tests (BUN and creatinine)—within normal limits
Electrolytes and glucose—within normal limits
Antinuclear antibody (ANA)—negative
Antithyroid peroxidase antibody (anti-TPO)—negative
Antithyroglobulin antibody (anti-TG)—positive
TSH-receptor antibody (TRAb)—negative
Total thyroxine hormone (T4)—low
Thyroid stimulating hormone (TSH)—high

Quizplus · Accepted Answer

The patient's symptoms of fatigue, weight gain, and a puffy face, along with laboratory findings of high TSH, low T4, and positive antithyroglobulin antibody (anti-TG), are indicative of Hashimoto's thyroiditis, an autoimmune disorder leading to hypothyroidism.

A 45- Year- Old Female Was Evaluated for Fatigue, Lethargy