As a long bone grows in length, new cartilage cells are produced on the epiphyseal side of the epiphyseal plate and bone replaces cartilage on the diaphyseal side of the plate.

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During the growth of a long bone, new cartilage cells are produced on the epiphyseal side (towards the ends) of the epiphyseal plate, which is a region of cartilage that allows for the bone to grow in length. On the diaphyseal side (towards the shaft) of the plate, the cartilage is replaced by bone, contributing to the lengthening of the bone.

As a Long Bone Grows in Length, New Cartilage Cells