The bone tissue of the distal region of the femur is replaced about every 4 months, whereas some regions of the shaft of the femur may never be replaced.

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Bone remodeling is a lifelong process where mature bone tissue is removed from the skeleton (a process called bone resorption) and new bone tissue is formed (a process called ossification or new bone formation). The rate of turnover varies significantly throughout the skeleton and by the type of bone. The distal region of the femur undergoes more frequent remodeling due to its role in weight-bearing and responding to mechanical stress, whereas the cortical bone in the shaft of the femur, being more dense and less metabolically active, may have areas that undergo very little to no replacement over a lifetime.

The Bone Tissue of the Distal Region of the Femur