Cells from advanced malignant tumors often have very abnormal chromosomes and an abnormal number of chromosomes. What might explain the association between malignant tumors and chromosomal abnormalities?
A) Cancer cells are no longer density-dependent.
B) Cancer cells are no longer anchorage-dependent.
C) Cell cycle checkpoints are not in place to stop cells with chromosome abnormalities.
D) Transformation introduces new chromosomes into cells.

Question

Quizplus · Accepted Answer

Cell cycle checkpoints normally prevent cells with chromosomal abnormalities from continuing to divide, but cancer cells often have mutations that disable these checkpoints, allowing them to continue dividing despite the abnormalities.

Cells from Advanced Malignant Tumors Often Have Very Abnormal Chromosomes