Which of the following is not a piece of evidence that supports the radial loop-scaffold model of DNA packaging?
A) Histone-depleted metaphase chromosomes still maintain their X-like shapes.
B) Electron micrographs of whole-mounted mitotic chromosomes show loops of chromatin at the periphery of the chromosomes.
C) Topoisomerase II assists in 100Å packaging.
D) Special,irregularly spaced repetitive base sequences associate with nonhistone proteins to define the chromatin loops.
E) All of the choices are such evidence.

Question

Quizplus · Accepted Answer

Topoisomerase II is involved in the process of DNA supercoiling and untangling, which is a different aspect of DNA manipulation than the structural packaging into loops as described in the radial loop-scaffold model.

Which of the Following Is Not a Piece of Evidence