Which Are Physiologic Changes During Pregnancy That Affect Drug Absorption,metabolism,distribution,and

Which are physiologic changes during pregnancy that affect drug absorption,metabolism,distribution,and excretion? (Select all that apply.)

A) Circulating steroid hormones
B) Decreased gastrointestinal motility
C) Decreased renal perfusion
D) Increased maternal circulatory blood volume
E) Poor sleep and fatigue