A Drawback of All Inactivated Vaccines Is That

A drawback of all inactivated vaccines is that

A) they are likely to cause disease in immunocompromised hosts.
B) they may mutate to a more virulent form.
C) they require complex genetic engineering techniques to produce.
D) they may cause secondary transmission from the immunized person to another host.
E) they are quickly cleared from the body, limiting antigen exposure.