Plaque reduction neutralization tests are based on the fact that

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Plaque reduction neutralization tests measure the ability of antibodies in a patient's serum to prevent viral infection of cells in culture. This is based on the principle that if the patient's serum contains antibodies against a specific virus, those antibodies will bind to the virus and neutralize it, thereby preventing it from infecting the cells in the culture. This results in a reduction of the number of plaques formed, which are areas of cell death caused by viral infection.

Plaque Reduction Neutralization Tests Are Based on the Fact That